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KMID : 1206220060130020099
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Journal of Korean Academy of Physical Therapy Science
2006 Volume.13 No. 2 p.99 ~ p.119
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Endothelin-l as a Regulator of Vascular Smooth Muscle Contraction-related Signal Transduction and Endothelin-l-induced Pain-related Nociception -The Approach of Basic Physical Therapy for the Study of Pain Specialized Physical Therapy-
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Kim Jung-Hwan
Lee Sook-Hee
Lee Sang-Bin
Choi Yoo-Rim
Kim Bo-Kyung
Park Ju-Hyun
Koo Ja-Pung
Choi Wan-Suk
An Ho-Jung
Choi Jeong-Hyun
Kim Moo-Gi
Kim Soon-Hee
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Abstract
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Endothelin (ET) is a 21 amino acid peptide with multifunctional effects on the vasculature as well as a variety of other cell types such as respiratory, gastrointestinal, urogenital, endocrine, central nervous systems, and others. Endothelin has emerged as a modulator by autocrine and paracrine actions for many cellular activities, including vasoconstriction, cell proliferation, hormone production, neurotransmitter and/or neuromodulator. The endothelin family consists of three closely related peptides, ET-1, ET-2, and ET-3 derived from separate genes, such as chromosome 6, 1, and 20, respectively. ET-1 is the predominant isoform produced in the cardiovascular system and about which most is known. Endothelin receptors are seven-transmembrane GTP-binding protein-coupled receptors, which are classified into endothelin-A (ETA) and endothelin-B (ETB) receptors. Interestingly, recent evidence is accumulating to suggest that ET -1 may contribute to a variety of pain states such as allodynia and hyperalgesia in animals and humans. Therefore, in this review the biological characteristics and contraction-related mechanism of endothelin-1 in mammalian cells will be summarized. Especially, we focus on multifunctional roles for ET-1 in noxious stimulation-induced pain for the study of pain specialized physical therapy.
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KEYWORD
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Endothelin, Pain, Contraction, Signal transduction, Pain specialized physical therapy
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